Intrinsically disordered region (IDR) is the physical substantial of LLPS droplet formation.[31] We estimated the IDRs of CRC TFs using PONDR (http://www.pondr.com/)[32] and found that some TFs, such as EHF, and PPARG in the CRC did not show IDRs, while other TFs, including NR3C1, had IDRs (Figure4A; Figure S6, Supporting Information). The gene discussed is PPARG; the disease is colorectal carcinoma.