AKT1 and cancer: The CCM is mainly involved in glycolysis, the pentose phosphate pathway, and the tricarboxylic acid cycle (TCA cycle).[20] Abnormal CCM contributes to cancer stemness maintenance and redox imbalance,[20] thereby enhancing resistance to chemotherapy drugs.[21] Cellular signaling pathways, including the PI3K‐AKT, ErbB, and FoxO pathways, were enriched.