In this study, we have crafted a signature including eight genes related to PCD (FLT3, SORL1, CD8A, BCL2L11, COL13A1, MPG, DYRK2 and CAMK2B) utilizing data from 339 patients diagnosed with less‐defined subtype DLBCL across multiple public datasets and the JSPH cohort. Here, DYRK2 is linked to diffuse large B-cell lymphoma.