AGT and hypertensive disorder: In VSMCs from hypertensive patients and AngII-induced hypertension models, the TRPV4/AKAP150/α1AR/PKC molecular complex was increased, enhancing the contribution of TRPV4 channels to vasoconstriction (Fig. 3A), whereas the TRPV4/RyR/BKCa channel molecular complex was decreased (Fig. 3B) [29].