AGT and hypertensive disorder: In an AngII-induced hypertension model created in caveolin1 knockout mice, no difference was observed in systemic blood pressure, but phosphorylation of EGFR, upregulation of caveolin1 and adventitial VCAM1, medial thickening, and fibrosis were suppressed in the aorta, coronary artery, and renal artery [94].