Our results showed that compared to the Lv-si-NC group, downregulation of IGF2BP2 remarkably elevated the m6A levels of Spon2, but reduced the mRNA levels of Spon2 in tumor tissues of mice, suggesting that downregulation of IGF2BP2 could reduce Spon2 levels in tumor tissues via the modulation of m6A methylation. The gene discussed is IGF2BP2; the disease is neoplasm.