INSR and pancreatic adenocarcinoma: As INSR is one of the central factors of MetS (Cornier et al. 2008; Jha et al. 2023), we analyzed overall survival with high and low INSR transcripts among three different chronic health conditions: pancreatic adenocarcinoma, liver hepatocellular carcinoma, and lung adenocarcinoma (Fig. 4d–f).