In final, a total of 50 core targets with 873 edges were screened out, and TNF (162), IL6 (157), AKT1 (157), IL1B (142), and PPARG (136) were the top 5 targets according to their degree values, and PTGS2 also has a relatively high degree value of 109, which were all considered as the key anti-NAFLD targets of WSF. The gene discussed is PPARG; the disease is metabolic dysfunction-associated steatotic liver disease.