For instance, activation of CAR by CITCO (6-(4-Chlorophenyl)imidazo[2,1-b][1,3]thiazole-5-carbaldehyde-O-(3,4-dichloro benzyl)oxime), a human CAR-specific agonist, inhibited the growth and expansion of brain tumor stem cells16. This evidence concerns the gene NR1I3 and brain neoplasm.