Key IgG targets include the nucleoprotein (N) and the spike (S1) glycoprotein’s receptor-binding domain (RBD), both major structural viral proteins of SARS-CoV-213–15 S1 interacts with the human ACE2 receptor, facilitating viral entry, whereas RBD is a specific binding site within S1 targeted by neutralizing antibodies16 Understanding the persistence of these antibodies post-infection is essential for evaluating immunity, especially in the context of vaccination. This evidence concerns the gene PSMD1 and infection.