Utilizing the Kaplan–Meier Plotter, it was observed that a reduced GPR37 mRNA level correlated with suboptimal overall survival (OS) in patients with ESCC, as evidenced in the TCGA ESCC, GSE53622, and GSE5324 datasets (Fig. 1I–K). This evidence concerns the gene GPR37 and esophageal squamous cell carcinoma.