The wound healing (Fig. 8I and Supplementary Fig. 9G), transwell (Fig. 8J and Supplementary Fig. 9H), and apoptosis (Fig. 8K and Supplementary Fig. 9I) experiments indicated that Exo-GPR37 suppressed the migration, invasion of ESCC cells and enhanced their radiosensitivity, respectively. This evidence concerns the gene GPR37 and esophageal squamous cell carcinoma.