Rab GTPases (Rabs) is the largest family of small GTPases, serving as multifaceted organizers of almost all membrane trafficking processes, including virus traffic in cells.16 The cycling of Rab GTPases between the membrane and cytoplasm is precisely regulated by various proteins.17 Rab GDP dissociation inhibitors (GDIs) bind to membrane-bound Rabs and extract Rabs from the membrane, thereby enabling Rabs’ availability for subsequent round of membrane delivery.18 The distribution of Rab is believed to have an impact on viral infection; however, this field has not been sufficiently researched. Here, AGFG1 is linked to viral infectious disease.