FAAH and psychotic disorder: Here, we investigate, for the first time, the role of the endocannabinoid system (eCB) in cognition in these populations as the eCB regulates neuronal signaling in the human brain9–13 and shows alterations at various levels in psychosis.14 One of the most abundant endogenous cannabinoids in the human brain, Narachidonoylethanolamide, anandamide, acts mostly on cannabinoid 1 (CB1) receptors15 and is catabolized primarily by fatty acid amide hydrolase (FAAH16).