Furthermore, subsequent co-culture of basolateral detached DCs derived from HIV-exposed IEDC with target cells resulted in HIV-1 transmission to U87.CD4.CCR5 cells through cell-cell contact [S3B–S3D Fig], which underscores the productive HIV-1 infection of basolateral DCs upon apical viral exposure. The gene discussed is CCR5; the disease is HIV-1 infection.