In this study, we examined the effect and underlying mechanism of CAPE on TBNC, with the following objectives: (1) to elucidate the inhibitory effect of CAPE on cell proliferation and its stimulatory effect on apoptosis in TNBC cells, (2) to investigate the potential mechanisms by which CAPE acts in TNBC cells, specifically its influence on ferroptosis and the AMPK and Foxo3 signaling pathways, (3) to investigate the contribution of AMPK and Foxo3 to the anti-tumor activity of CAPE, and (4) to validate the anti-tumor efficacy and mechanism of CAPE in vivo. Here, FOXO3 is linked to neoplasm.