Aligned with our findings, narrative reviews discussed the renal dysfunction associated with leptospirosis that resulted in secretion/expression of Fibronectin [62], iNOS [62–66], CCL2/MCP-1 [62, 63, 65, 66], TNFα [62, 64–66], NFκB [62, 67], CCL2/MIP2 [66], CXCL1/KC [66] through TLR2. This evidence concerns the gene CXCL2 and leptospirosis.