TLR2 involvement during the pathogenesis response against leptospirosis was observed through the decrease of IL1β, TNFα [17, 56], IL6 [17], NFκB, and IL10 [56] secretion/expression due to deficient/knocked down of the TLR2 receptors [17, 56]. This evidence concerns the gene NFKB1 and leptospirosis.