By analyzing the differentially expressed genes of Pro-mac and Anti-mac cells, we found IL10, PDCD1LG2, PDGF, VEGF, MMP9, CXCL9, CXCR4, IL22, KLF4, and TGF-β were highly expressed in Pro-mac cells that promote tumor growth, angiogenesis, and suppress tumor immunity (Figure 6f). Here, KLF4 is linked to neoplasm.