We found that 11 proteins had a significant association with rheumatic disorders with Bonferroni correction (eTable 13 in Supplement 1), namely, interleukin-27, ICAM5, LMAN2L with JIA; TIMP4 with SSc; and 6 proteins with RA, and 4 proteins with SLE (Figure 3). This evidence concerns the gene ICAM5 and rheumatoid arthritis.