KEGG analysis further indicated the involvement of SFRPs in various pathways, including the Wnt signaling pathway, proteoglycans in cancer, signaling pathways regulating stem cell pluripotency, PI3K-Akt signaling pathway, CRC, AMPK signaling pathway, mRNA surveillance pathway, and other pathways related to CRC (Fig. 3C). This evidence concerns the gene AKT1 and colorectal carcinoma.