IL1R1 and neoplasm: In our data, we had observed consistent change in IL1R1 and IL1B in long versus short telomere tumours and also noted that IL1 signalling has been widely implicated with TAM infiltration in multiple cancers (Carmi et al., 2009; Chittezhath et al., 2014; Lappano et al., 2020; Mantovani et al., 2019).