However, particularly because macrophages are known to be a rich source of IL1B (Carmi et al., 2009; Arango Duque and Descoteaux, 2014; Mantovani et al., 2018), and given the model-specific changes in inflammatory cytokines noted by us, further experiments will be required to understand how telomeres influence paracrine/ juxtracrine IL1 signalling between cancer cells and TAM. Here, IL1B is linked to cancer.