Because phosphorylation of PKM2 at serine 37 is dependent on ERK1/2 (Yang et al., 2012) and TIPE promotes AML chemoresistance by activating the ERK signaling pathway (Pang et al., 2020), we used an ERK inhibitor to further demonstrate the activation of HIF-1α induced by TIPE. This evidence concerns the gene HIF1A and acute myeloid leukemia.