Interestingly, nuclear PKM2 also functions as a coactivator for several transcription factors, such as HIF-1α (Luo et al., 2011; Wang et al., 2014) or Oct4 (Yang et al., 2018), by which regulates metabolic gene transcription and promotes tumorigenesis or sustains cancer stem cell (CSC) populations. This evidence concerns the gene PKM and cancer.