Peptidylglycine alpha-amidating monooxygenase, an essential protein in the biosynthesis of many neural and endocrine peptides and hormones, has previously been linked to the regulation of blood pressure through its interaction with atrial natriuretic peptides, as well as a predictor for different cardiovascular disease, including heart failure [77,78,79]. The gene discussed is NPPA; the disease is cardiovascular disorder.