HMOX1 and hemolytic-uremic syndrome: HO-1 levels in the kidneys of Stx-challenged Hmox1lox/lox (Figure 1B; n = 12 per group) and Hmox1R26∆/∆ (Figure 1C; n = 15 per group) mice were significantly elevated 7 days after HUS induction compared to their corresponding sham group.