In light of the residual HO-1 levels observed in the kidneys of Hmox1R26Δ/Δ mice in this study, it is pertinent to consider the findings in the existing scientific literature, which raises the question of whether a constitutive Hmox1 knockout might have resulted in further differences in kidney damage and disease progression in mice with HUS, as has been observed in other disease contexts [8,11,21,52,53]. Here, HMOX1 is linked to hemolytic-uremic syndrome.