Previous evidence also indicated that MC-LR can aggravate liver lipid metabolism disorders in obese mice by activating the PI3K/AKT/mTOR/SREBP1 signaling pathway in hepatocytes, resulting in elevated levels of key enzymes for lipid synthesis regulated by SREBP1-c, as well as blocking fatty acid β-oxidation [39]. This evidence concerns the gene SREBF1 and digestive system neoplasm.