FANCD2 and neoplasm: Moreover, incorporating transcriptomic and proteomic results, the present study identified further information: LIG1 plays an important role in DNA replication, repair, and recombination, and LIG1 defunction has been associated with impaired DNA replication and repair [26]; MDM2 plays a crucial role in regulating the activity of p53, the critical tumor suppressor [27]; and FANCD2 is important for repairing DNA inter-strand crosslinks [28].