VEGFA and central nervous system cancer: Previous reviews have indicated a more frequent incidence of tumoral hemorrhage in malignant neoplasms, such as higher-grade gliomas (e.g., glioblastoma), and brain metastases [5,71], potentially because of the underlying angiogenic factors (e.g., vascular endothelial growth factor) that are more activated in malignant tumor cells [46,52] during their rapid growth [26].