Finally, Hp-induced vacuolating cytotoxin A (VacA), displays chemotactic activities toward bone marrow-derived MCs (BMD-MCs) and induces them to produce pro-inflammatory cytokines that, in addition to causing local pathologies [127], lead to disruptions of the blood–brain barrier (BBB) and the blood-ocular barrier (BOB), resulting in neuropathies such as MS, AD and glaucoma, the latter referred to as ‘ocular AD’ [128]. The gene discussed is HP; the disease is Alzheimer disease.