For the first time, we described the inhibitory effects of Hal on AChE activity in the striatum, hippocampus, and septo-hippocampal system, brain-specific regions with significant cholinergic system activity, and it is known that their dysregulation is involved in the mechanism of catalepsy [33,34], and Alzheimer’s disease [35]. Here, ACHE is linked to early-onset autosomal dominant Alzheimer disease.