Based on the findings of this study, we conclude that the aqueous artichoke bract extract contains bioactive polyphenols capable of preventing lipid metabolism disorders, oxidative stress, and fatty liver disease by regulating the expression of key proteins, including HMG-CoA reductase, ApoA-1, SREBP-2, PCSK-9, p-AMPK, and CYP2E1. Here, PCSK9 is linked to fatty liver disease.