Ischemic conditions affecting these processes result in mitochondrial dysfunction and the development of disease conditions such as cardiovascular disease, stroke, etc. The cluster of proteins labeled in purple, such as the myosin regulatory light polypeptides 2, 3, 4, 6, and 9, plays a primary role in striated muscle contraction by regulating the movement of myosin head molecules for cross-bridge formation. This evidence concerns the gene MYH14 and cardiovascular disorder.