Researchers who applied linalool to the HeLa cell line observed increased expression in genes including TP53 (encoding the p53 tumor suppressor protein), CDKN1A (p21), CDKN1B (p27), CDKN2A (p16), and CDKN2C (p18), all of which facilitate and direct tumor suppression [76]. This evidence concerns the gene CDKN1A and neoplasm.