The mechanism of inhibiting proliferation was determined in another study, which showed this characteristic in human bladder cancer as well as induction of apoptosis, cellular migration, and invasion by hesperetin via mediation of the PI3K/Akt/FoxO3a pathways and induction of cell-cycle arrest at the G0/G1 phase [105]. This evidence concerns the gene AKT1 and urinary bladder cancer.