CDH2 and hypospadias: 1. Increased development of hypospadias in offspring2. Mice with hypospadias showed decreased epithelial markers (E-cadherin) and increased mesenchymal markers (N-cadherin and VIM) in the genital tubercles 3. Increased concentration of NAP-24. Maternal exposure to DBP can lead to excessive production of NAP-2, excessively activating the epithelial–mesenchymal transition of urothelial cells in the genital tubercles and contributing to the development of hypospadias in the male offspring