AR and imperforate anus: 1. In PND1, 39.5% incidence of anorectal malformations in male offspring with anal atresia and accumulated meconium2. Decreased body weight and anogenital distance3. In male rats with anorectal malformations, the blind side of the terminal rectum was covered in intestinal epithelium4. DBP exposure suppresses androgen production and AR expression, interfering with the activation of androgen-related genes, such as Shh and Fgf10, and leading to the abnormal expression of downstream factors, contributing to the development of anorectal malformations