1. Exposed male offspring with a 43.64% incidence of hypospadias2. Decreased anogenital distance and genital tubercle volume3. Decreased testosterone in rats with hypospadias4. Decreased apoptosis and increased autophagy5. Decreased expression of Akt, mTOR and S6 in the genital tubercle of rats with hypospadias, and inhibition of the PI3K/AKT/mTOR pathway increased autophagy in the genital tubercles of fetuses exposed to DBP. The gene discussed is MTOR; the disease is hypospadias.