TP53 and hypospadias: 1. Higher position of the testicles in the DBP-exposed group2. The incidences of hypospadias and cryptorchidism at PND45 were 37.5% and 65.6%, respectively, while of both simultaneously it was 31.3%3. Increased expression of BcI-2 protein in the embryonic mouse testis and inhibition of germ cell apoptosis4. Increased expressions of the pro-apoptotic proteins Bax and p53 in the testes of pubertal rats, leading to the increased apoptosis of germ cells and Sertoli cells