Besides this, when comparing the effects of DBP exposure between the groups with and without anorectal malformations, it was found that the expression of Wnt5a decreased markedly in the group with anorectal malformations, suggesting that DBP may induce anorectal maldevelopment by disturbing the signaling pathway mediated by Wnt5a [62]. The gene discussed is WNT5A; the disease is anorectal malformation.