1. Increased development of hypospadias in offspring2. Mice with hypospadias showed decreased epithelial markers (E-cadherin) and increased mesenchymal markers (N-cadherin and VIM) in the genital tubercles 3. Increased concentration of NAP-24. Maternal exposure to DBP can lead to excessive production of NAP-2, excessively activating the epithelial–mesenchymal transition of urothelial cells in the genital tubercles and contributing to the development of hypospadias in the male offspring. This evidence concerns the gene CDH1 and hypospadias.