In cardiometabolic diseases, insulin resistance and alterations in glucose and lipid homeostasis contribute to endothelial dysfunction that develops because of increased oxidative stress, reduced NO production, and increased secretion of adipokines, endothelin-1, and fibroblast growth factor 2, which stimulate inflammation, intimal growth, angiogenesis, and smooth muscle cell proliferation [177,178]. This evidence concerns the gene EDN1 and endothelial dysfunction.