INS and Hyperinsulinemia: In visceral fat, there is a higher turnover of lipids than in other fat depots, with a greater sensitivity of catecholamine-induced lipolysis and decreased sensitivity to insulin anti-lipolysis, with a subsequent increase in plasma free fatty acids, triglycerides, and very low-density lipoprotein cholesterol; reduced HDL-C level; and peripheral hyperinsulinemia [52].