Recognized by the World Health Organization (WHO) as a Chronic Non-Communicable Disease (CNCD) [5], MetS has been associated with CVD which, in turn, is correlated with the progression of atherosclerosis in response to chronic inflammation and vascular endothelial dysfunction and T2DM, mainly due to disturbances in insulin secretion, action and IR [6]. The gene discussed is INS; the disease is type 2 diabetes mellitus.