Mutations in several NaV-α subunits were associated with epilepsy, including NaV1.1 (SCN1A), NaV1.2 (SCN2A), NaV1.3 (SCN3A), NaV1.6 (SCN8A), and NaV1.7 (SCN9A) [74]. This evidence concerns the gene SCN3A and epilepsy.