In addition, it was noted that decreased B4GalT-5 expression in glioma cells caused a decrease in polylactosamine synthesis and selectively depleted CD133+ cells in the xenograft, thereby suppressing the ability of glioma cells to engage in self-renewal, which suggests an interesting role for B4GalT-5 in the formation of polylactosamine on N-glycans, which appears to be one of the molecular carbohydrate signatures of glioma stem cells [37]. Here, B4GALT5 is linked to central nervous system cancer.