Reduced expression of MAN1A1 in glioma stem cells leads to the synthesis of high-mannose N-glycan on the CD133 glycoprotein, which is required for the CD133-DNMT1 interaction, which mediates the maintenance of glioma cells in the stemness state, enhancing drug resistance and tumorigenesis [25]. The gene discussed is MAN1A1; the disease is central nervous system cancer.