In rhinology, periostin has been studied extensively for its role in Th2-mediated inflammation, particularly in conditions like chronic rhinosinusitis (CRS) and its subtypes, including eosinophilic chronic rhinosinusitis (ECRS) and chronic rhinosinusitis with nasal polyps (CRSwNP) [4]. This evidence concerns the gene POSTN and chronic rhinosinusitis with nasal polyps.