This is due to various factors, including the variability of the cortisol test itself, cortisol metabolism (11-beta-hydroxysteroid dehydrogenase) during sepsis, corticosteroid binding globulin concentrations, tissue factors (for example, elastase and anti-glucocorticoid compounds) and cellular (for example, glucocorticoid receptor). Here, NR3C1 is linked to Sepsis.