Among the samples, 76.5% (52/68) were positive for S-100, 94.1% (64/68) for HMB-45, 83.6% (56/67) for Melan-A, 100% (29/29) for SOX-10, and 76% (19/25) for PRAME (preferentially expressed antigen in melanoma). The gene discussed is MLANA; the disease is melanoma.