The advent of recent research has shown that semaglutide not only potentiates insulin secretion and alleviates insulin resistance by inducing glucose transporter type 4 (GLUT4) in insulin-sensitive target tissues, mainly skeletal muscle and adipose tissue, but also presents exceptional anti-inflammatory and mitochondrial biogenesis regulating effects, mitigating oxidative stress [21,22]. Here, INS is linked to Insulin resistance.