In addition, circFBXW7 is an antioncogenic product encoded by the Fbxw7 protein that acts as a tumor suppressor, and circFBXW7 is down-regulated as a result of mutation in hepatocellular carcinoma (HCC) and esophageal cancer, clarifying the role of Fbxw7 in the mechanism of HCC development [28,29]. This evidence concerns the gene FBXW7 and hepatocellular carcinoma.