By regulating the splicing of transcripts such as Fibronectin 1 (Fn1), which plays a role in cell adhesion and migration; Neuropilin 2 (Nrp2), involved in angiogenesis and neuronal development; Sirtuin 2 (Sirt2), a deacetylase associated with cellular stress responses and the regulation of senescence; Osterix (Sp7), a key transcription factor for osteoblast differentiation; and Secreted Phosphoprotein 1 (Spp1), which regulates bone mineralization and bone metabolism, YBX1 affects the osteogenic differentiation and senescence of BMSCs, ultimately mediating the progression of osteoporosis [91]. Here, SPP1 is linked to osteoporosis.