For example, MS-275 promotes YBX1 acetylation at K81, enhancing its binding to the 3′UTR region of Nuclear Factor Erythroid 2-Related Factor 2 (NRF2) mRNA, which increases NRF2 translation and decreases ROS in sarcoma cells, ultimately inhibiting sarcoma metastasis [32]. Here, YBX1 is linked to sarcoma.