The authors also showed that a member of the mammalian target of rapamycin (mTOR) C2 complex, RICTOR, can bind to PRICKLE1 and that PRICKLE1-MINK1-RICTOR complex integrity is essential for AKT (protein kinase B, PKB) activation, focal adhesion regulation, as well as migration of cancer cells. Here, PRICKLE1 is linked to cancer.