The kinase takes part in various immunological processes, suppressing Th17 and Th1 cell differentiation, regulating the secretion of cytokines and NLRP3 inflammasome activation, thus influencing the progression and severity of inflammatory states and autoimmunological diseases that involve the mentioned components, including sepsis, rheumatoid arthritis, asthma, SLE and others. This evidence concerns the gene NLRP3 and Sepsis.