PBRM1 mutation is also found in many cancers including cholangiocarcinoma, lung adenocarcinoma (LUAD), bladder urothelial carcinoma (BLCA), skin cutaneous melanoma (SKCM), and non-small cell lung cancer (NSCLC) [30,34,35,36]. The gene discussed is PBRM1; the disease is bladder transitional cell carcinoma.