ST6GAL1 and cancer: In addition, α2,3-specific sialyltransferases were overexpressed in the stromal compartment of human CRC tissues compared to the epithelial fraction, while the expression of ST6GAL1 and ST6GAL2 (α2,6 linkage-specific sialyltransferases) was increased in human CRC cancer-associated fibroblasts (CAFs) compared to the controls.