SPP1 and cancer: Specifically, SPP1 was found to be upregulated in several cancers, including BLCA, BRCA, CESC, CHOL, COAD, ESCA, GBM, HNSC, KIRP, LIHC, LUAD, LUSC, PRAD, READ, STAD, THCA, and UCEC (Figure 2).