It has been suggested that VEGF inhibitor in combination with chemotherapy could enhance PD-L1 inhibitor-induced T cell-mediated cancer cell death, by reversing VEGF-induced immunosuppression by promoting the infiltration of T cells into the tumor microenvironment and enabling T cell activity against tumor antigens, as well as chemotherapy-induced cancer cell death [57]. The gene discussed is VEGFA; the disease is neoplasm.