Recent advancements in understanding the pathophysiology of cancer cachexia have identified potential therapeutic targets, including tumor-derived mediators such as leukemia inhibitory factor (LIF) [50], zinc alpha glycoprotein (ZAG) [51,52], activin A [53], and growth differentiation factor 15 (GDF-15) [54,55]. The gene discussed is AZGP1; the disease is neoplasm.