The mean TDP-43 concentration in the ALS serum group was 477 pg/mL (95% CI of the mean between 430 and 573 pg/mL) versus that of a 948 pg/mL mean in the healthy controls (95% CI of the mean between 765 and 1108 pg/mL), with p = 0.001 using an unpaired t-test. Here, TARDBP is linked to amyotrophic lateral sclerosis.