Given that CIN is known to enhance the malignant potential of tumors [46,47] and considering the findings of Wang et al. that STIL promotes tumor cell proliferation and invasion in NSCLC [27], it is likely that the increased malignant phenotype resulting from STIL overexpression contributes to the worsened pathological stage observed in NSCLC patients with elevated STIL expression. This evidence concerns the gene STIL and neoplasm.