Given that CIN is known to enhance the malignant potential of tumors [46,47] and considering the findings of Wang et al. that STIL promotes tumor cell proliferation and invasion in NSCLC [27], it is likely that the increased malignant phenotype resulting from STIL overexpression contributes to the worsened pathological stage observed in NSCLC patients with elevated STIL expression. The gene discussed is STIL; the disease is non-small cell lung carcinoma.