An event observed in many melanoma patients at the advanced stage consisted of a low level of copy number gains of at least one BRAF-containing allele, occurring in 78% of patients with BRAF-mutant melanomas and in 15% of BRAF-WT melanomas; in all patients with BRAF-mutant melanomas, with only one exception, the gained BRAF allele was the mutated allele [29]. Here, BRAF is linked to melanoma.