A sequential genomic and transcriptomic analysis extending from nevi up to regional metastases allowed the definition of pathways activated or disrupted during melanoma evolution; somatic alterations sequentially induced NAPK pathway activation, the upregulation of telomerase, the modulation of the chromatin landscape, G1/S checkpoint override, the ramp-up of MAPK signaling, the disruption of the p53 pathway and the activation of the PI3K pathway [35]. Here, TP53 is linked to melanoma.